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Keep track of Intently (one)pentobarbital will lessen the level or result of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to a lessen in fentanyl plasma concentrations, lack of efficacy or, potentially, progress of a withdrawal syndro